Fluorinated Pyridine Intermediates Into Hot Spots
Nov 30, 2018

At present, our country has developed and has been put into mass production of quinolones antimicrobial drugs are mainly norfloxacin, ciprofloxacin, Ofloxacin, norfloxacin, Lomé Sand Star, fleroxacin and so on.

The production of Norfloxacin, Ciprofloxacin and Ofloxacin was the largest, accounting for about 98% of the total production of fluoroquinolones in China. Quinolones are generally condensed with piperazine (or methyl piperazine) by the synthesis of fluorine-containing benzene ring compounds. Due to the abundant reserves of fluorite in China, it is one of the countries with the largest production of fluorinated drugs and intermediates in the world, and more than 80% of the fluorinated intermediates are supplied for export. On the whole, the development of fluorine intermediates in China is early, and there is a general surplus of production capacity at present. The development of Trifluoromethane intermediates is late, and the development rate is faster in recent years, and for heterocyclic aromatic compounds, especially fluorinated pyridine, only individual research units and manufacturers in China currently have the synthesis technology of fluorinated intermediates, therefore, Fluorinated pyridine intermediates will become one of the main directions for the development of fluorinated intermediates in China in the next few years.


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